Andrew U. Meyer
Andrew U. Meyer received the Ph.D. in electrical engineering from Northwestern University in 1961. Between 1961 and 1965 he was a Member of the Technical Staff at Bell Laboratories at Whippany, New Jersey, where he was engaged in research on automatic control problems pertaining to satellite attitude control and missile autopilots. Prior to his graduate studies, between 1950 and 1957, he held engineering positions with Associated Research, Inc., Sun Electric Corporation and Armour Research Foundation of Illinois Institute of Technology, all in Chicago, Illinois.
In 1965, Dr. Meyer joined the Electrical Engineering Department of New Jersey Institute of Technology, Newark, New Jersey, as an Associate Professor, became a Professor in 1968 and Professor Emeritus in 2002. During the academic year 1969-1970, he was a Visiting Professor at Middle East Technical University, Ankara, Turkey. Dr. Meyer´s research interests involve automatic control theory and its applications, with emphasis on biomedical system dynamics. Since 1972 he is also on the adjunct research faculty of the University of Medicine and Dentistry of New Jersey, since 1980 as an Adjunct Research Professor in the Department of Ophthalmology. His publications include co-authorship (with Jay C. Hsu) of the book "Modern Control Principles and Applications", McGraw-Hill 1968.
- Northwestern University, M.S., 1958.
- Northwestern University, Ph.D., 1961.
Institute of Electrical and Electronics Engineers (IEEE), Society for Industrial and Applied Mathematics (SIAM), American Association for the Advancement of Science (AAAS), New York Academy of Sciences (NYAS), Association for Research in Vision and Ophthalmology (ARVO), American Association of University Professors (AAUP), Sigma Xi, Eta Kappa Nu.
IEEE Control System Society: Member of Standards Committee, 1963-69; North Jersey Chapter of IEEE Control System Society: Chairman, 1964-65; IEEE- New Technical and Scientific Activities Committee (NTSAC), New York Section, member 1965 - 1990, Secretary 1967-68); American Automatic Control Council (AACC): Member of Biomedical Systems Committee (representing IEEE), 1972-84, International Federation of Automatic Control (IFAC): Committee on Biomedical Engineering, 1972-84. IEEE –: Liaison Representative of both Division X and Control Systems Society to Society on Social Implications of Technology, 1995 – present; Sigma Xi, NJIT Chapter: Board Member: 1979 – present, Secretary: 1979-82, President: 1996 – present.
Who´s Who in the East, American Men and Women of Science, Who´s Who in Computer Education and Research, International Scholars Directory.
MODELING IN CLINICAL ELECTROPHYSIOLOGY OF THE EYE:
Collaborator: Edward J. Haupt, Montclair State College and UMDNJ.
Students: Ken-Gen Lu, MS 1988; NJ Zhongquan Li, MS 1991; Juan J. Castro, MS 1992; Hui-Zhong Pan, MS 1992; Sung-Hoon Jang,MS 1993; Kehul Banker, MS 1994; Peter H. Derr, MS 1999.
Mathematical modeling of electrophysiological signals such as the visual evoked potential (VEP), electroretinogram (ERG) or electrooculogram (EOG) can provide systematic quantification of clinical test results. Rather than relying merely on selected signal features such as peak-to-trough values, latencies etc., modeling facilitates "compression" of the entire signal into a set of finite parameters. Moreover, it allows physiological knowledge, though limited, to be used to obtain some degree of separation of the contributing elements. In a continuing effort, the measurement system including both hardware and software, developed earlier, is being updated and improved. Testing activity during the last years concentrated on electroretinography. In addition to the data compression of the ERG into a finite set of parameters, a new model developed appears to allow separation of its a- wave and b-wave components. In other studies, models of the oscillating potential of the ERG have been obtained, which are presently being evaluated. It is anticipated to examine ERG test data from different laboratories to establish meaningful ranges of the model parameters.
VISUAL SYSTEM MODELING INVOLVING THE VEP:
Collaborators: Vance Zemon, PhD, Albert Einstein College of Medicine and Laboratory for Biophysics, The Rockefeller University.
Students: Zongqi (George) Hu, MS, PhD 1994, Rey Favis, doctoral student.
The human visual evoked potential (VEP) can be considered to be generated by various sources in a multilayer neural network. Some neuronal functions and the transfer characteristics of particular processing pathways can be analyzed by use of carefully designed VEP stimuli. Experimental work had been performed at the Biophysics Laboratory of Rockefeller University and is continuing at Albert Einstein College of Medicine. The work focusses on studies of the VEP as a composition of such neuronal activity as direct-through excitation, local lateral inhibition and contrast gain control mechanisms. Both frequency response and transient behavior are considered in the model. Current work aims at model extentions to include earlier VEP activity as well as improvements of the parameter estimation process.
SLOW, RED-GREEN COUNTERPHASE (PARVO) AND FAST, BLACK-WHITE (MAGNO) SNOW IN THE DETECTION OF SCOTOMATA IN PRIMARY OPEN-ANGLE GLAUCOMA:
Collaborator: Edward J. Haupt, PhD, Montclair State College and UMDNJ.
Student: Rey Favis, MS 1993.
No one knows why Primary Open Angle Glaucoma sufferers can detect blindspots by monocularly fixating on a mark in the center of a screen of television snow. An attempt was made to determine which of two pathways from retina to lateral geniculate nucleus is more involved in the detection of the blindspots. Previous studies demonstrated that the large diameter axon, magno cellular pathway is maximally stimulated by 30 Hertz high contrast black-white patterns. The small diameter axon, parvo cellular pathway is known from past research to be maximally stimulated by 12 Hertz red-green counterphase patterns. It was found that patients, when vieving a black-white noise presentation (snow) could more accurately determine glaucoma induced blindspots than when viewing a 5 Hertz red-green counterphase pattern. The possible presence of visual pathway fiber damage in the patients was indicated by subnormal results from a spatial frequency test that utilized a neutral density filtered Visitech chart.
LOCALIZATION OF LESIONS IN THE HUMAN NERVOUS SYSTEM BASED ON NEUROLOGICAL TESTS:
Collaborators: Rose A. Dios (major contributor), Mathematics Department, NJIT, William K. Weissman,MD, Menlo Park, CA.
Student: Yusuf Parlar, PhD 1990.
This project is based upon a process for localization of lesions in the nervous system introduced by Meyer and Weissman in 1973, where knowledge of the anatomy of neural pathways is used to translate clinical neurological test outcomes into a map which identifies location(s) of probable lesion(s) as well as areas of neural function. In the original work, indicators were introduced to denote the severity of lesion in each given area. In the recent work, these indicators have been related to estimates of lesion probability, using regression analysis, Monte Carlo simulation and logistic modeling.
BAYESIAN METHODS IN RISK ASSESSMENT FOR CARDIAC SURGERY:
Collaborators: Rose A. Dios (major contributor), Mathematics Department, NJIT, Victor Parsonnet, Daniel Bernstein and Michael Gera, Newark Beth Israel Medical Center.
Students: Julie Teng, MS 1993 (student of Rose A. Dios), Arifa Zafir, MS 1994 (student of A.U. Meyer).
Subjective probability techniques are used to estimate the probability of mortality for cardiac surgery patients in different "overall risk" categories. Confidence regions for the risk values are also under investigation.
IDENTIFICATION/COUNTER MODEL DYNAMICS IN C3 SYSTEMS:
Collaborators: Israel Mayk, US Army Research and Development Command, Ft. Monmouth, NJ, Denis Blackmore, Mathematics Department, NJIT.
Students: John Clarke, MS 1987, moved to Carnegie-Mellon University. Sofia Monzka, MS 1989, now with Kearfott Division of Astronautics Corporation of America.
A primitive model for a class of C3 system had been considered, containing modules involving both identification (ID) and counter (CO) dynamics. Each module includes both decision making and initiation of actions. The relatively simple model involves two opposing forces in terms of their (average) locations along one dimension. This model can exhibit transitions between different modes of dynamic behavior (bifurcations) within irregular ranges of initial conditions. The dynamics of this model can be represented in both tabular and graphic forms that allow prediction of the modes of behavior for given initial conditions. It is anticipated that this representation will help toward the eventual aim of finding criteria for existence and avoidance of particular dynamic modes.
Books or Book Chapters
"Extraction and Modeling of the Oscillatory Potential: Signal Conditioning to Obtain Minimally Corrupted Oscillatory Potentials", P.H. Derr, A.U. Meyer, E.J. Haupt, M.G. Brigell, Documenta Ophthalmologica, Kluwer Academic Publishers, vol.104, n.1, January 2002, pp.37-55.
"Predictive Value of ERG Parameters Following Acute CRVO" M.G. Brigell, A.U. Meyer, P.J. Derr, E.J. Haupt, Associstion for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, April 29 - May 4, 2001, Abstracts, vol.42, n.4, p.S237.
"Evaluation of the 14 dB Bright Electroretinograms of an NEI CRVO Study to Determine if a Statistical Separation of Oscillatory Potential Model Parameters Exists in a Population of Fellow Eyes and Diagnosed CRVO Eyes", A.U. Meyer, P.J. Derr, E.J. Haupt, M.G. Brigell, Associstion for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, April 30 - May 5, 2000, Abstracts, vol.41, n.4, p.S243.
"Realization of a Prefiltering Technique used in the Extraction of the Oscillatory Potential from the Electroretinogram", P.J. Derr, A.U. Meyer, E.J. Haupt, M.G. Brigell, Associstion for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, May 9-14, 1999, Abstracts, vol.40, n.4, p.S16.
"Comparison of 1- and 2-Envelope Models of Frequency and Amplitude Parameters of Electroretinogram Oscillatory Potentials for Identification of CRVO Eyes," E.J. Haupt, P. Derr, A.U. Meyer, M.G. Brigell, Associstion for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, May 9-14, 1999, Abstracts, vol.40, n.4, p.S16.
"Objective Determination of Signal from Noise in Swept-Parameter Transient Visual Evoked Potentials (VEPS)", V.M. Zemon, S. Buckley, K.M. Fitzgerald, J. Gordon, E.E. Hartmann, A. Meyer, Associstion for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, May 9-14, 1999, Abstracts, vol.40, n.4, p.S824.
"Model Fitting for a Frequency Parameter in Signal Conditioned Oscillatory Potentials from Electroreninograms of CRVO Eyes", E.J. Haupt, P. Derr, A.U. Meyer, M.G. Brigell, Associstion for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, May 10-15, 1998, Abstracts, vol.39, p.S181.
"A Signal Conditioning Approach for Extraction of the Oscillatory Potential from the Electroretinogram", P. Derr, A.U. Meyer, M.G. Brigell, E.J. Haupt, Associstion for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, May 10-15, 1998, Abstracts, vol.39, p.S181.
"A Swept-Parameter Transient Visual Evoked Potential (VEP) Technique for the Study of Visual Development", V. Zemon, S.W. Buckley, K.M. Fitzgerald, J. Gordon, E.E. Hartman, A.U. Meyer, M.B. Monalto, Associstion for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, May 11-16, 1997, Abstracts, vol.38, p.S992.
"Retrospective Comparison of CRVO Diagnosed and Non-Diagnosed Eyes which did and did not later showed Neovascularization by an OP Signal" , E.J. Haupt, A.U. Meyer, M.G. Brigell, Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, May 11-16, 1997, Abstracts, vol.38, p.S880.
"Signal Modeling of Oscillatory Potentials: Separation of Rod, Cone, and Cone-Rod Components", E.J. Haupt, A.U. Meyer, E. King-Smith, K. Banker, Association for Research in Vision and Ophthalmology (ARVO), Annual Meeting, Fort Lauderdale, FL, April 21-26, 1996, Abstracts, p. S348.
"Control System Analysis and Design Upon the Lyapunov Method", S. Lyashevskiy, A.U. Meyer, American Control Conference, Seattle, WA, June 1995, Proceedings, pp.3219-3223.
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